Alendronate Drug Holidays

jampack 33 (2003) 301307 www.elsevier.com/locate/ oculus sinister Alendronate has a residue operation on arise mass in postmenopausal Danish women up to 7 years aft(prenominal) battle cry withdrawal Yu Z. Bagger,* Laszlo B. Tanko, Peter Alexandersen, Pernille Ravn, and Claus Christiansen ´ ´ ´ Center for Clinical and Basic inquiry A/S, Ballerup Byvej 222, Ballerup, Denmark Received 4 shew 2003; accepted 15 March 2003 Abstract Alendronate has been shown to reduce bone disorder and subjoin bone mass. However, little is known about the sequence of the import on bone aft(prenominal) treatment withdrawal. The aim of this impart was to investigate the long-term effects on bone mineral density (BMD) and bone turnover of variant alendronate regimens afterward treatment withdrawal. In this study, we followed 203 postmenopausal women who previously participated in 2 alendronate randomized placebo-controlled trials. Daily oral treatment with mingled doses of al endronate (2.520 mg) were given for 2, 4, or 6 yr followed by no treatment for 7, 5, or 3 yr, respectively. machinate mineral density of the lumbar spine, hip, and forearm was measured by dual-energy x-ray absorptiometry. Biochemical markers of bone turnover were induced argument serum C-terminal telopeptides of type I collagen (CTX) and osteocalcin. Women who received alendronate (2.

510 mg per day) for 2 yr had a 3.8% higher(prenominal) BMD compared to those receiving placebo when assessed 7 yr after withdrawal. The residual effect was proportionally larger in women who had received treatment for 4 (5.9%, P 0.02 ) or 6 yr (8.6%, P 0.002), respectively. How! ever, the largest residual effect was found in women treated with alendronate 20 mg per day for 2 yr (9.7%, P 0.01 vs. placebo). The rate of bone loss after alendronate withdrawal was comparable to the bone loss find in the placebo group. Bone markers tended to reverse butt to normal levels, only if were still affected even several(prenominal) years after withdrawal of treatment. This study has demonstrated that the ef?cacy of...If you indispensableness to get a full essay, order it on our website: OrderCustomPaper.com

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